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Familial melanoma

8 OMIM references -
6 associated genes
12 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

1 OMIM reference -
1 associated gene
22 signs/symptoms

Familial melanoma

ADULT syndrome

CDK4	(UniProt - OMIM)		TP63	(UniProt - OMIM)
CDKN2A	(UniProt - OMIM)
CDKN2B	(UniProt - OMIM)
CDKN2D	(UniProt - OMIM)
MC1R	(UniProt - OMIM)
TERT	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	CDKN2A	(0.68)	TP63

Citations in the biomedical literature:

Familial melanoma		ADULT syndrome
	Synonym(s): (no synonyms)		Synonym(s): - Acro-dermato-ungual-lacrimal-tooth syndrome - Pigment anomaly - ectrodactyly - hypodontia

	Classification (Orphanet): - Rare eye disease - Rare genetic disease - Rare oncologic disease - Rare skin disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare odontologic disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 8 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C538052


COMMON SIGNS	- Dry / squaly skin / exfoliation - Excessive freckling

Familial melanoma		ADULT syndrome
	Very frequent - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Melanoma Frequent - Anomalies of the lymphatic system - Hair and scalp anomalies Occasional - Autosomal dominant inheritance - Breast neoplasm / tumor / carcinoma / cancer - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Extrapyramidal syndrome - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Retinopathy		Very frequent - Anomalies of eyelids, eyelashes and lacrimal system - Anomalies of teeth and dentition - Chronic skin infection / ulcerations / ulcers / cancrum - Dysplastic / thick / grooved fingernails - Dysplastic / thick / grooved toenails - Fine hair - Nails anomalies - Oligodactyly / ectrodactyly of toes - Pigmented naevi / naevus pigmentosus / lentigo - Syndactyly of fingers / interdigital palm - Syndactyly of toes - Thin skin Frequent - Alopecia - Breast tissue / mammary gland absence / aplasia - Hypoplastic / absent nipples - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness - Tooth shape anomaly Occasional - Broad nose / nasal bridge - Face / facial anomalies - High nasal bridge